I've just switch themes. Switched layouts a few times, but didn't find anything that worked better for me. Darker theme now. Still need to tweak the default link colors and such, but it's good.
Finally browbeat the '@media handheld' portion of my custom stylesheet into submission. Need to test it on an actual handheld (I was using '@media screen' to test) and make sure it works. Mainly, it kills the lj bar, the header, the sidebar, and all the margins/padding around the content. Nothing worse than trying to read my friends page and having all the /crap/ cause the /content/ to be rendered one-word-per-line.
I'm pondering switching back to S1. Except I think my custom S1 style is gone, and I don't want to spend the time writing a new one.