So, other than the slight inflammation last week, the only reactions I've had to the Niaspan have been the night AFTER the night I increased the dose. Started 500mg on a thursday, problem friday night. Ditto the next friday at 1g. Ditto last friday at 1500mg. But then, last night, same problem again. This is getting REALLY annoying. One more increase, to 2g, this thursday.. I need to schedule an appointment with my doc for next week to a) bitch about the side-affects and b) run tests to see how well this crap's working.